ELC8 - ELC8 – Puberty: HPG Axis Maturation

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Covers the hormonal control of puberty including GnRH, LH/FSH, sex steroids, kisspeptin, and maturation of the HPG axis from childhood to adult function.

Created by

Millicent C

Australia

Download the paper version to play

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ELC8 - ELC8 – Puberty: HPG Axis Maturation


ELC8 - ELC8 – Puberty: HPG Axis MaturationOnline version Covers the hormonal control of puberty including GnRH, LH/FSH, sex steroids, kisspeptin, and maturation of the HPG axis from childhood to adult function. by Millicent C 1 Early life HPG axis activity From mini-puberty after birth to childhood suppression. Brief activation of HPG axis after birth “mini-puberty” Strong negative feedback maintains low sex steroid levels HPG axis enters suppressed state Postnatal decline of GnRH, LH, and FSH secretion Temporary rise in LH, FSH, and sex steroids Low-amplitude circadian GnRH pulses secretion persists 2 Pre-pubertal to early pubertal transition From pre-pubertal state to early pubertal activation. Gonadotropins become less sensitive to negative feedback; HPG axis begins switching on. Kisspeptin neurons activate GnRH neurons, positive feedback overcomes HPG axis suppression Increased GnRH pulse frequency and small amplitude peaks in early hours of morning during sleep (diurnal pattern) Similar sex-hormone binding globulin levels exist in people with ovaries and testes, binding most circulating sex steroids pre-puberty 3 Early puberty to maturation shift From early puberty to adult pulsatility pattern. LH and FSH pulses occur primarily during sleep Gonadal sex steroid production increases and secondary sexual characteristics begin to appear LH and FSH pulses become more frequent during the day Loss of diurnal rhythm in GnRH/LH/FSH secretion begins 4 HPG axis signalling Hormone signalling from pituitary to gonads. LH and FSH are released into circulation Kisspeptin stimulates GnRH neurons in hypothalamus LH stimulates Leydig/theca cells and FSH stimulates Sertoli/granulosa cells Testosterone, oestradiol, and progesterone production increases Spermatogenesis and ovarian cycle GnRH stimulates anterior pituitary gonadotrophs 5 Adult reproductive function From late puberty to full maturity. Mature gonadal steroid production maintained Continuous pulsatile GnRH release across the day Established loss of diurnal rhythm in GnRH secretion Testosterone decreases sex hormone binding globulin; oestrogen increases SHBG. Full fertility and adult reproductive function achieved. Stable pulsatile GnRH/LH/FSH signalling

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ELC8 - ELC8 – Puberty: HPG Axis Maturation

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About this activity

Created by

Download the paper version to play

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ELC8 - ELC8 – Puberty: HPG Axis MaturationOnline version

by Millicent C

Early life HPG axis activity From mini-puberty after birth to childhood suppression.

Pre-pubertal to early pubertal transition From pre-pubertal state to early pubertal activation.

Early puberty to maturation shift From early puberty to adult pulsatility pattern.

HPG axis signalling Hormone signalling from pituitary to gonads.

Adult reproductive function From late puberty to full maturity.