Foggy Jump: HCl Secretion

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Basics of gastric acid production

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Dhamayanthi murali

India

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Froggy Jumps Foggy Jump: HCl SecretionOnline version Basics of gastric acid production by Dhamayanthi murali 1 Where is the H+/K+ ATPase (proton pump) located in the stomach? a Chief cells of the gastric mucosa b Parietal cells of the gastric mucosa c G cells in the antrum 2 What is the primary driving force for H+ secretion into the stomach lumen? a Active transport by the H+/K+ ATPase b Passive diffusion c Facilitated diffusion via CFTR 3 Which ion is exchanged with H+ by the proton pump to secrete HCl? a K+ b Ca2+ c Na+ 4 Which enzyme/bicarbonate is involved in neutralizing the blood after HCl secretion? a Carbonic anhydrase producing bicarbonate b Renin c Pepsin 5 What stimulates parietal cells to secrete acid? a Secretin and cholecystokinin only b Gastric inhibitory peptide (GIP) only c Histamine, gastrin, and acetylcholine acting on receptors 6 Which ion pathway allows Cl- to follow H+ into the lumen? a Sodium-glucose cotransporter b Potassium channels only c Chloride channels (CFTR) 7 What role does gastrin play in acid secretion? a Inhibits somatostatin release b Directly neutralizes acid c Stimulates parietal cells indirectly via ECL and D cells 8 Which cell type secretes bicarbonate-rich mucus to protect the stomach lining? a Chief cells b Parietal cells c Mucous cells (surface mucous cells) 9 What happens to HCl secretion when somatostatin is released? a Direct conversion to CO2 b Inhibition of acid secretion c Activation of proton pumps 10 Which drugs commonly reduce gastric acid secretion by blocking the proton pump? a Antacids like aluminum hydroxide b Proton pump inhibitors (PPIs) c H2 receptor antagonists only

Froggy Jumps

Foggy Jump: HCl SecretionOnline version

Basics of gastric acid production

by Dhamayanthi murali

Where is the H+/K+ ATPase (proton pump) located in the stomach?

Chief cells of the gastric mucosa

Parietal cells of the gastric mucosa

G cells in the antrum

What is the primary driving force for H+ secretion into the stomach lumen?

Active transport by the H+/K+ ATPase

Passive diffusion

Facilitated diffusion via CFTR

Which ion is exchanged with H+ by the proton pump to secrete HCl?

K+

Ca2+

Na+

Which enzyme/bicarbonate is involved in neutralizing the blood after HCl secretion?

Carbonic anhydrase producing bicarbonate

Renin

Pepsin

What stimulates parietal cells to secrete acid?

Secretin and cholecystokinin only

Gastric inhibitory peptide (GIP) only

Histamine, gastrin, and acetylcholine acting on receptors

Which ion pathway allows Cl- to follow H+ into the lumen?

Sodium-glucose cotransporter

Potassium channels only

Chloride channels (CFTR)

What role does gastrin play in acid secretion?

Inhibits somatostatin release

Directly neutralizes acid

Stimulates parietal cells indirectly via ECL and D cells

Which cell type secretes bicarbonate-rich mucus to protect the stomach lining?

Chief cells

Parietal cells

Mucous cells (surface mucous cells)

What happens to HCl secretion when somatostatin is released?

Direct conversion to CO2

Inhibition of acid secretion

Activation of proton pumps

Which drugs commonly reduce gastric acid secretion by blocking the proton pump?

Antacids like aluminum hydroxide

Proton pump inhibitors (PPIs)

H2 receptor antagonists only

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Foggy Jump: HCl Secretion

Froggy Jumps

About this activity

Created by

Download the paper version to play

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Foggy Jump: HCl SecretionOnline version

by Dhamayanthi murali

Where is the H+/K+ ATPase (proton pump) located in the stomach?

What is the primary driving force for H+ secretion into the stomach lumen?

Which ion is exchanged with H+ by the proton pump to secrete HCl?

Which enzyme/bicarbonate is involved in neutralizing the blood after HCl secretion?

What stimulates parietal cells to secrete acid?

Which ion pathway allows Cl- to follow H+ into the lumen?

What role does gastrin play in acid secretion?

Which cell type secretes bicarbonate-rich mucus to protect the stomach lining?

What happens to HCl secretion when somatostatin is released?

Which drugs commonly reduce gastric acid secretion by blocking the proton pump?

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