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AINEs: conceptos clave

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AINEs: conceptos clave

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Conceptos y mecanismos

Created by

Fernanda Aguilar
Fernanda Aguilar
Mexico

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AINEs: conceptos clave
 

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AINEs: conceptos claveOnline version

Conceptos y mecanismos

by Fernanda Aguilar
1

Los AINEs ( Antiinflamatorios No Esteroideos ) son medicamentos que disminuyen el dolor , la inflamación y la fiebre mediante la inhibición de la enzima ciclooxigenasa ( ) , reduciendo la producción de .

2

Los AINEs producen tres efectos principales : ? disminuyen el dolor ; ? reducen la inflamación ; ? disminuyen la fiebre .

3

Los AINEs inhiben la enzima ( COX ) , evitando que el se transforme en y tromboxanos . Al disminuir las prostaglandinas se reduce : dolor , inflamación , fiebre .

4

Las son sustancias derivadas del que participan en inflamación , dolor , fiebre , protección gástrica , flujo sanguíneo renal y .

5

Las ciclooxigenasas ( COX ) son enzimas responsables de producir prostaglandinas . Existen dos principales : y .

6

es una enzima constitutiva , siempre presente y con función principal de proteger tejidos sanos ; funciones : protege la , mantiene el flujo sanguíneo renal , favorece la , produce prostaglandinas fisiológicas .

7

Qué ocurre si se inhibe ? Disminuye la protección del organismo y pueden ocurrir , , y .

8

Qué es ? Es una enzima que solo aumenta cuando existe inflamación .

9

Funciones de COX - 2 : produce que ocasionan , dolor , y .

10

Clasificación : inhiben y ; AINEs preferenciales COX - 2 inhiben principalmente COX - 2 ; inhiben solo COX - 2 .

11

AINEs no selectivos incluyen , Diclofenaco , Ketoprofeno , Ketorolaco , Indometacina , Fenilbutazona ; preferenciales COX - 2 incluyen , Etodolaco ; selectivos COX - 2 incluyen , Robenacoxib , Firocoxib .

12

Efectos terapéuticos : ( disminuye el dolor ) ; ( disminuye inflamación ) ; ( disminuye fiebre ) .

13

Efectos adversos : , , vómito , diarrea , hemorragia digestiva , , .

14

Contraindicaciones : no administrar AINEs en , , enfermedad hepática grave , , shock , hemorragias , .

15

Medicamentos : , ( ventaja : menor daño gastrointestinal ) , ( selectivo COX - 2 ) , Robenacoxib , Firocoxib , ( bloquea , no inhibe COX ) .

 
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