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TPA vs Clot Retrieval

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TPA vs Clot Retrieval

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TPA vs Clot Retrieval

Created by

OLIVIA JEAN-ALAIRE FLEMING
OLIVIA JEAN-ALAIRE FLEMING
Australia

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TPA vs Clot RetrievalOnline version

TPA vs Clot Retrieval

by OLIVIA JEAN-ALAIRE FLEMING
1

In an acute ischaemic stroke , a blocks cerebral blood flow , causing deprivation and reduced ATP production . Failure of the Na ? / K ? - ATPase leads to cellular swelling and increased intracellular , contributing to neuronal injury .

tPA is a that converts plasminogen ? , which breaks down in the clot . It is given intravenously , ideally within hours , and is quick and non - invasive . However , it is less effective for large clots and increases the risk of intracranial haemorrhage .

Mechanical thrombectomy physically removes the clot using a . It is particularly effective for large vessel occlusions , has high rates , and may be used up to hours in selected patients . Its limitations are the need for specialist services and procedural risks .

After blood flow is restored , injury can occur . Damaged generate reactive oxygen species ( ROS ) , causing oxidative stress , inflammation and further neuronal injury . Reperfusion also activates inflammatory cells and - 9 , which damages the blood - brain barrier .

Blood - brain barrier breakdown increases vascular permeability , causing vasogenic and potentially haemorrhagic transformation . tPA may increase this risk because it promotes and can worsen blood - brain barrier disruption .

 
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