Fill in the Blanks HOUSE OF MEDICIOnline version Some facts about the House of Medici. by Alfonso Poza 1 Renaissance rule masters patron popes House humanities banking Magnificent tombs Europe The Medici family , also known as the of Medici , became important in Florence in the 13th century through its success in commerce and . Beginning in 1434 with the rise to power of Cosimo de ? Medici the family ? s support of the arts and made Florence the cradle of the . Cosimo was a devoted of the humanities , supporting artists such as Ghiberti , Brunelleschi , Donatello and Fra Angelico . During the of his grandson , Lorenzo the ( 1449 - 1492 ) , Florence became the cultural center of . He supported the work of such Renaissance as Botticelli , Leonardo da Vinci and Michelangelo ( whom the Medici commissioned to complete their family in Florence ) . Along its history , the House of Medici produced four ( Leo X , Clement VII , Pius IV and Leon XI ) .