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COVID-19: Molecular Entry Puzzle

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COVID-19: Molecular Entry Puzzle

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About this activity

Spot the cellular doorway the virus targets.

Created by

Mohammed Zahir Khan
Mohammed Zahir Khan
Kazakhstan

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COVID-19: Molecular Entry Puzzle
 

COVID-19: Molecular Entry PuzzleOnline version

Spot the cellular doorway the virus targets.

by Mohammed Zahir Khan
1

A doorway on human cells that the virus seeks to open.

Hints

Serves as the cellular receptor exploited by SARS-CoV-2.

Expressed in tissues such as the lungs and intestines.

It's a host protein used by the virus to enter cells.

2

A simple act that helps stop germs from spreading.

Hints

A widely promoted public health habit to reduce transmission.

Do this after using the bathroom, after coughing or sneezing, and before eating.

Wet hands, apply soap, and rub for at least 20 seconds.

3

A tiny invader with a crown-like appearance that started a global crisis.

Hints

First identified in late 2019, Wuhan, China.

It binds to ACE2 receptors via a spike protein.

Causes a disease named COVID-19.

4

A specific protein on my surface helps me attach to human cells and enter them.

Hints

A major target for vaccines and antibodies.

Interacts with a receptor to gain entry into cells.

Forms the characteristic crown-like appearance under a microscope.

5

I reside on the cell surface, acting as the doorway that SARS-CoV-2 uses to gain entry.

Hints

Also involved in regulating blood pressure.

Binds the viral spike protein to facilitate entry.

A receptor found on many human cells, including lungs.

6

An antiviral drug repurposed to interfere with viral replication in some COVID-19 cases.

Hints

Used in hospital settings for certain patients.

Inhibits viral RNA synthesis.

Originally developed for other viruses before COVID-19.

7

A diagnostic method that detects viral RNA from patient samples.

Hints

Requires specialized laboratory equipment.

Amplifies genetic material to detectable levels.

Gold standard for diagnosing active infection in many guidelines.

8

A vaccine platform that uses messenger RNA to instruct cells to produce an immune target.

Hints

Examples include vaccines developed against SARS-CoV-2.

Leads to production of an immune response without infection.

Encodes the viral antigen rather than the whole pathogen.

9

A basic epidemiological metric representing the average number of secondary cases from an infected individual in a fully susceptible population.

Hints

Not a fixed value; depends on context.

Can change with interventions and population immunity.

Used to gauge contagiousness in the early phase of an outbreak.

 
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