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Glucólisis: Explicación Esencial

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Glucólisis: Explicación Esencial

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Explicación clara de la glucólisis.

Created by

Leidy Salas
Leidy Salas
Peru

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Glucólisis: Explicación Esencial
 

Glucólisis: Explicación EsencialOnline version

Explicación clara de la glucólisis.

by Leidy Salas
1

Introducción a la glucólisis

La glucólisis es la ruta metabólica que convierte la glucosa en piruvato, generando energía y intermediarios para otras vías celulares.

2

Ubicación y contexto

La glucólisis ocurre en el citoplasma y es anaeróbica, funcionando sin necesidad de oxígeno, aunque puede conectarse con la respiración celular cuando hay oxígeno disponible.

3

Paso 1: Activación de la glucosa

La glucosa se transforma en glucosa-6-fosfato mediante la hexocinasa, consumiendo una molécula de ATP para iniciar la ruta.

4

Paso 2: Isomerización

La glucosa-6-fosfato se convierte en fructosa-6-fosfato por la fosfohexosa isomerasa, preparando la molécula para la ruptura posterior.

5

Paso 3: Fosforilación de fructosa

La fructosa-6-fosfato se fosforila a fructosa-1,6-bisfosfato mediante la PFK-1, la enzima reguladora clave de la ruta.

6

Paso 4: Ruptura de la molécula

La fructosa-1,6-bisfosfato se divide en dos triosas: DHAP y G3P, mediante la aldolasa.

7

Paso 5: Interconversión de triosas

DHAP se convierte en G3P por la triosa fosfato isomerasa, quedando una única molécula de G3P para continuar.

8

Paso 6: Oxidación y generación de NADH

El G3P se oxida, formando 1,3-bisfosfoglicerato y NADH; la enzima clave es la gliceraldihído-3-fosfato deshidrogenasa.

9

Paso 7: Primeros movimientos de fosforilación

Se produce ATP por fosfoglicerato quinasa y se forma 3-fosfoglicerato como intermediate, conservando energía para la célula.

10

Paso 8: Preparación para piruvato

El 3-PG se convierte en 2-PG, luego en PEP y finalmente en piruvato con piruvato quinasa, produciendo más ATP.
 
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