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TB: Dosis, Tratamiento e Interacciones

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TB: Dosis, Tratamiento e Interacciones

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Riddles sobre TB, dosis y fármacos

Created by

Camila Sepulveda
Camila Sepulveda
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TB: Dosis, Tratamiento e Interacciones
 

TB: Dosis, Tratamiento e InteraccionesOnline version

Riddles sobre TB, dosis y fármacos

by Camila Sepulveda
1

Soy un fármaco clave en TB que puede provocar neuropatía si no se me acompaña de una vitamina, y mi metabolismo depende de variantes genéticas de acetilación. ¿Quién soy?

Pistas

Interacciones y dosis pueden variar con el estado hepático y la velocidad de acetilación del paciente; alcohol y otros fármacos pueden aumentar mi riesgo de efectos adversos.

Puedo causar hepatotoxicidad y neuropatía periférica; se recomienda suplementación de vitamina B6 (piridoxina) para prevenirlo.

Se usa en el esquema standar RIPE y se metaboliza principalmente por NAT2 (acilación rápida o lenta).

2

Soy un antibiótico que es un potente inductor de enzimas hepáticas, tiñe de naranja los fluidos corporales y reduce la eficacia de varios fármacos; a menudo aparezco en tratamientos TB y en combinaciones complejas. ¿Quién soy?

Pistas

Interacciones con anticonceptivos orales, anticoagulantes y otros fármacos pueden requerir ajuste de dosis o alternativas terapéuticas.

Puedo teñir de naranja la orina, sudor y lágrimas; este efecto es característico pero inofensivo.

Soy un inductor enzimático fuerte (incrementa el metabolismo de muchos fármacos).

 
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