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Benzo DIÁLOGO: Benzodiacepinas en 10 pasos

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Benzo DIÁLOGO: Benzodiacepinas en 10 pasos

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Resumen visual de conceptos clave

Created by

EduAr145
EduAr145
Mexico

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Benzo DIÁLOGO: Benzodiacepinas en 10 pasos
 

Benzo DIÁLOGO: Benzodiacepinas en 10 pasosOnline version

Resumen visual de conceptos clave

by EduAr145
1

Slide 1: Introducción

Las benzodiacepinas (BZD) revolucionaron la medicina del siglo XX para la ansiedad, insomnio y convulsiones. Imágenes: historia y uso clínico.
2

Slide 2: Mecanismo de acción

Modulan, no sustituyen al GABA-A. Intervienen como alostéricos positivos, aumentando la acción inhibitoria y la calma neuronal. Imagen de sinapsis.
3

Slide 3: Receptor GABA-A

Receptor pentamérico con canal de Cl−. Sitio BZD entre α y γ. Subunidades como α1 sedación; α2/α3 ansiedad.
4

Slide 4: Hiperpolarización

Entrada de Cl− hiperpolariza la neurona, dificultando el disparo. Explica la reducción de crisis y ansiedad. Imagen de flujo iónico.
5

Slide 5: Farmacocinética I

Las BZD son lipofílicas; cruzan la BHE velozmente. Diazepam se redistribuye a tejido graso; efectos a veces persisten.
6

Slide 6: Farmacocinética II

Hígado: Fase I (CYP450) y Fase II (conjugación LOT). Apto en insuficiencia hepática; metabolitos y vida media variable.
7

Slide 7: Clasificación por vida media

Ultracorta, corta, intermedia y prolongada. Indicaciones: sedación, insomnio, ansiedad y deshabituación. Imagen de cronología de duración.
8

Slide 8: Aplicaciones clínicas

Psiquiatría y neurología: ansiedad, status epiléptico, espasticidad. Uso controlado; puede ser puente terapéutico y en crisis. Imagen clínica.
9

Slide 9: Efectos y riesgos

Efectos: sedación, ataxia, amnesia. Riesgo aumentado en tercera edad; Beers. Síndrome de abstinencia con tormenta adrenérgica.
10

Slide 10: Consideraciones finales

Prescripción responsable y educación son clave. Potencial de dependencia; buscar alternativas a largo plazo y estrategias psicoterapéuticas. Imagen educativa.
 
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