Infection, Tumor, Therapy Quiz

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nuclear medicine

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Joshua Liberty

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April 15, 2024

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Infection, Tumor, Therapy QuizOnline version Quiz we received in class by Joshua Liberty 1 The mechanism of action for Cu-64 dotatate is : binds to various plasma protiens, including transferrin and lactoferrin. a True b False 2 Larger particles of Tc99m SC are generally recommended in lymphoscintigraphy as more frequent visualization of lymphatic channels is acheived. a True b False 3 With lymphoscintigraphy for melanoma, imaging begins immediately after injection and is repeated at 5 minute intervals for 45 to 60 minutes. a True b False 4 Usual dose of Ga-67 citrate is 1-3 mCi. a True b False 5 With Ga-67 citrate, the reason for delayed views is concentration in tissue is stable while blood clearence improves over time. a True b False 6 With In-111 Oxine labeled WBCs, early lung activity occurs, then clears out. a True b False 7 With In-111 Oxine labeled WBCs, uptake in liver and spleen is abnormal at 24 hours. a True b False 8 Leukocyte agents are nonspecific and alo localize in areas of inflammation, without infection. a True b False 9 Sestamibi breast imaging should be delayed 2 weeks following FNA and 4-6 weeks post core biopsy a True b False 10 The main disadvantage with In-111 Oxine WBC imaging is the tag to WBCs begins to breakdown leading to renal and GI excretion-this complicates GI infection localization. a True b False 11 A tech cannot find a vein on a In-111 WBC patient; he can try using a 25g needle to draw blood with no effect on the scan. a True b False 12 Tilmanocept is DTPA-mannosyl-dextran, a macromolecule with an average diameter of between 100 and 220 nm. a True b False 13 Lu-177 can be imaged with a gamma camera a True b False 14 The hypothetical first lymph node or group of nodes reached by metastasizing cancer cells from a tumor is called? a Axillary lymph node b Inguinal lymph node c Sentinel lymph node d Lymphedema 15 A condition in which lymphatic fluid accumulates in soft tissues and may lead to inflammation and obstruction is called? a Lymphoma b Lymphatic cancer c Sentineal lymph node d Lymphedema 16 A patient has bilateral breast disease; where should the sestamibi be injected? a Right arm b Left arm c Right wrist d Left wrist e Foot 17 Drawbacks of In-11 Oxine labeled WBCs include? a Large volume of blood needed about 50 mL b 2-3 hour labeling process c Poor counts since small activity d Delayed views past 24 hours are count poor and low quality e All of the above 18 The MOL for sestamibi breast imaging is? a Compartmental b Receptor binding c Unknown, thought to be increased blood flow and metabolic rate in abnormal cells d Passive diffusion e Chemisorption 19 Ga-68 Dotatate recommended dose is? a 0.034 mCi/kg up to 4.4 mCi b 0.054 mCi/kg up to 5.4 mCi c 0.074 mCi/kg up to 7.4 mCi d 0.094 mCi/kg up to 5.4 mCi e 0.054 mCi/kg up to 9.4 mCi f 4 mCi 20 Normal distribution of Ga-68 Dotatate is seen in the ? a Choriod plexus of the brain b Pituitary gland c Glandular tissues of the neck d Liver e Choriod plexus of the brain, Pituitary gland, Glandular tissues of the neck f All of these 21 Ga-68 Dotatate is indicated for use with? a Gamma Camera imaging of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients b PET infection imaging c Therapy of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients d PET localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients 22 Cu-64 Dotatate dose is? a 4 mCi b 15-20 mCi c 6 mCi d 0.054 mCi/kg up to 5.4 mCi e 10-15 mCi 23 Regarding Cu-64 dotatate preperation, for patients on long-acting somatostatin analogs,a washout period of _____ is recommended prior to imaging. For patients on short-acting somatostatin analogs, a washout period of ____ is recommended prior to imaging. a 14 days; 2 days b 28 days; 2 days c 28 hours; 2 hours d 14 days; 7 days e 28 days; 4 days 24 Lutetium Lu-177 dotatate recommended dose is _______? a 100 mCi every 8 weeks for a total of 4 doses b 200 mCi every 8 weeks for a total of 4 doses c 200 mCi every 4 weeks for a total of 8 doses d 200 mCi every 2 weeks for a total of 4 doses 25 Lymphoscintigraphy may use a Co-57 flood source; this is called a? a Flow image b Transmission image c Emission image d Blood pool scan 26 ________ accumulates in lymphatic tissue and selectively binds to receptor ( CD206) located on the surface of macrophages and dendritic cells. a Ra-223 Dichloride b Tc99m Sulfur colloid c Tc99m MDP d Tc99m Tilmanocept e Cu-64 Dotatate 27 Before initating LUTATHERA: Discontinue long-acting somatostatin analogs (e.g., long-acting octreotide) for at least ______ weeks prior to initiating LUTATHERA. Administer short-acting octreotide as needed; discontinue at least ____ hours prior to inititating LUTATHERA. a 2; 24 b 6; 24 c 4; 24 d 4; 48 e 4; 72 28 Lu-177 Tp is? a 64 hours b 6.6 hours c 12.7 hours d 12.7 days e 6.6 days f 64 days 29 If 10 mL of 0.5% stock solution are placed in a flask and diluted to 50 mL, what is the concentration of the new solution. a 0.001% b 0.1% c 0.01% d 10% e 0.0001% Feedback 4 5-10 mCi 10 Agents are non specific and also localize in areas of inflammation, without infection. 11 21g has to be used or bigger due to hemolyisis of the cells from teh small needle. 12 It is Tc99m SC particles with an average diameter of between 100 and 220 nm. 13 It has a gamma ray energy therefore can be imaged. 29 (10 mL)(0.5%) / 50 mL = 0.1%

Infection, Tumor, Therapy QuizOnline version

Quiz we received in class

by Joshua Liberty

The mechanism of action for Cu-64 dotatate is : binds to various plasma protiens, including transferrin and lactoferrin.

True

False

Larger particles of Tc99m SC are generally recommended in lymphoscintigraphy as more frequent visualization of lymphatic channels is acheived.

True

False

With lymphoscintigraphy for melanoma, imaging begins immediately after injection and is repeated at 5 minute intervals for 45 to 60 minutes.

True

False

Usual dose of Ga-67 citrate is 1-3 mCi.

True

False

With Ga-67 citrate, the reason for delayed views is concentration in tissue is stable while blood clearence improves over time.

True

False

With In-111 Oxine labeled WBCs, early lung activity occurs, then clears out.

True

False

With In-111 Oxine labeled WBCs, uptake in liver and spleen is abnormal at 24 hours.

True

False

Leukocyte agents are nonspecific and alo localize in areas of inflammation, without infection.

True

False

Sestamibi breast imaging should be delayed 2 weeks following FNA and 4-6 weeks post core biopsy

True

False

The main disadvantage with In-111 Oxine WBC imaging is the tag to WBCs begins to breakdown leading to renal and GI excretion-this complicates GI infection localization.

True

False

A tech cannot find a vein on a In-111 WBC patient; he can try using a 25g needle to draw blood with no effect on the scan.

True

False

Tilmanocept is DTPA-mannosyl-dextran, a macromolecule with an average diameter of between 100 and 220 nm.

True

False

Lu-177 can be imaged with a gamma camera

True

False

The hypothetical first lymph node or group of nodes reached by metastasizing cancer cells from a tumor is called?

Axillary lymph node

Inguinal lymph node

Sentinel lymph node

Lymphedema

A condition in which lymphatic fluid accumulates in soft tissues and may lead to inflammation and obstruction is called?

Lymphoma

Lymphatic cancer

Sentineal lymph node

Lymphedema

A patient has bilateral breast disease; where should the sestamibi be injected?

Right arm

Left arm

Right wrist

Left wrist

Foot

Drawbacks of In-11 Oxine labeled WBCs include?

Large volume of blood needed about 50 mL

2-3 hour labeling process

Poor counts since small activity

Delayed views past 24 hours are count poor and low quality

All of the above

The MOL for sestamibi breast imaging is?

Compartmental

Receptor binding

Unknown, thought to be increased blood flow and metabolic rate in abnormal cells

Passive diffusion

Chemisorption

Ga-68 Dotatate recommended dose is?

0.034 mCi/kg up to 4.4 mCi

0.054 mCi/kg up to 5.4 mCi

0.074 mCi/kg up to 7.4 mCi

0.094 mCi/kg up to 5.4 mCi

0.054 mCi/kg up to 9.4 mCi

4 mCi

Normal distribution of Ga-68 Dotatate is seen in the ?

Choriod plexus of the brain

Pituitary gland

Glandular tissues of the neck

Liver

Choriod plexus of the brain, Pituitary gland, Glandular tissues of the neck

All of these

Ga-68 Dotatate is indicated for use with?

Gamma Camera imaging of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients

PET infection imaging

Therapy of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients

PET localization of somatostatin receptor positive neuroendocrine tumors (NETs) in adult and pediatric patients

Cu-64 Dotatate dose is?

4 mCi

15-20 mCi

6 mCi

0.054 mCi/kg up to 5.4 mCi

10-15 mCi

Regarding Cu-64 dotatate preperation, for patients on long-acting somatostatin analogs,a washout period of _ is recommended prior to imaging. For patients on short-acting somatostatin analogs, a washout period of is recommended prior to imaging.

14 days; 2 days

28 days; 2 days

28 hours; 2 hours

14 days; 7 days

28 days; 4 days

Lutetium Lu-177 dotatate recommended dose is _______?

100 mCi every 8 weeks for a total of 4 doses

200 mCi every 8 weeks for a total of 4 doses

200 mCi every 4 weeks for a total of 8 doses

200 mCi every 2 weeks for a total of 4 doses

Lymphoscintigraphy may use a Co-57 flood source; this is called a?

Flow image

Transmission image

Emission image

Blood pool scan

________ accumulates in lymphatic tissue and selectively binds to receptor ( CD206) located on the surface of macrophages and dendritic cells.

Ra-223 Dichloride

Tc99m Sulfur colloid

Tc99m MDP

Tc99m Tilmanocept

Cu-64 Dotatate

Before initating LUTATHERA: Discontinue long-acting somatostatin analogs (e.g., long-acting octreotide) for at least __ weeks prior to initiating LUTATHERA. Administer short-acting octreotide as needed; discontinue at least hours prior to inititating LUTATHERA.

2; 24

6; 24

4; 24

4; 48

4; 72

Lu-177 Tp is?

64 hours

6.6 hours

12.7 hours

12.7 days

6.6 days

64 days

If 10 mL of 0.5% stock solution are placed in a flask and diluted to 50 mL, what is the concentration of the new solution.

0.001%

0.1%

0.01%

10%

0.0001%

Feedback

5-10 mCi

Agents are non specific and also localize in areas of inflammation, without infection.

21g has to be used or bigger due to hemolyisis of the cells from teh small needle.

It is Tc99m SC particles with an average diameter of between 100 and 220 nm.

It has a gamma ray energy therefore can be imaged.

(10 mL)(0.5%) / 50 mL = 0.1%

Infection, Tumor, Therapy Quiz

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