Gluconeogenesis QuizOnline version For first MBBS students by Jayakala Thankiah 1 Which of the following is the key regulatory enzyme of gluconeogenesis? a Pyruvate carboxylase b Hexokinase c Phosphofructokinase-1 d Glycogen synthase 2 A patient with biotin deficiency may have impaired gluconeogenesis due to defective activity of which enzyme? a Pyruvate carboxylase b Phosphoenolpyruvate carboxykinase c Fructose-1,6-bisphosphatase d Glucose-6-phosphatase 3 Which of the following conditions will most likely stimulate gluconeogenesis? a Prolonged fasting b Increased insulin levels c High blood glucose levels d Increased availability of fructose-2,6-bisphosphate 4 A researcher is studying the effects of a new drug that inhibits phosphoenolpyruvate carboxykinase (PEPCK). What would be the expected metabolic consequence of this inhibition? a Decreased hepatic glucose production b Increased conversion of pyruvate to glucose c Increased glycolysis in liver cells d Increased utilization of glycogen stores 5 Why is gluconeogenesis not a simple reversal of glycolysis? a Because three irreversible steps in glycolysis need to be bypassed by different enzymes b Because glycolysis occurs in the cytoplasm while gluconeogenesis occurs in mitochondria c Because gluconeogenesis requires oxygen while glycolysis does not d Because glycolysis produces ATP whereas gluconeogenesis does not
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