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Gamboa II.5

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Gamboa II.5

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About this activity

Mecanismos microsomicos de oxidación e isoformas

Created by

Armando Peña
Armando Peña
Mexico

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Gamboa II.5
 

Gamboa II.5Online version

Mecanismos microsomicos de oxidación e isoformas

by Armando Peña
1

La oxidación es la ________ de electrones y la reducción es la ________ de ellos

2

El O2 esta incorporado a sustratos por:

3

P-450 es la identificación de unas proteínas hepáticas con un grupo hem

4

En donde son abundantes los citocromos p-450

5

El citocromo P-450 es específico para Hidrocarburos Aromáticos Policíclicos (PAH)

6

La función de los citocromos P-450 es detoxificacion, elimina sustancias endogenas por medio de agregación de grupos hidrofobos o lipofilos(medicamentos, carcinogenos)

7

El CYP-P450 funciona en el metabolismo endogeno degradando sustancias del organismo

8

Sustrato de la isoforma CYP1A2

9

Sustrato del CYP2B6

10

Inductor del CYP2C9

11

Sustrato del CYP2C19

12

Inhibidor del CYP2C8

13

Inhibidor del CYP2D6

14

Inductor del CYP3A4

Explicación

Es de sustancias exógenas

 
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