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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1

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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1

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Medications impacted by polymorphisms in HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1, and their associated toxicities.

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Sophia
Sophia
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PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1
 

PGx Week 12 Practice Quiz: HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1Online version

Medications impacted by polymorphisms in HLA-B, RYR1, CACNA1S, G6PD, and mtRNR1, and their associated toxicities.

by Sophia
1

Which of the following medications are impacted by HLA-B*15:02 polymorphisms? Select all that apply.

Choose one or more answers

2

Polymorphisms in which of the following alleles can impact how a patient tolerates carbamazepine? Select all that apply.

Choose one or more answers

3

A 35-year-old patient is being evaluated for initiation of abacavir as part of antiretroviral therapy. HLA genotyping results are as follows: HLA-A: *31:01 / *Y HLA-B: *15:02 / *X, *57:01 / *57:01 What is the most appropriate recommendation regarding abacavir therapy for this patient?

4

Which of the following anesthetics is safe to use in a patient who tests positive for inherited autosomal dominant pattern for both RYR1 and CACNA1S ("MHS causative" variants)?

5

Which of the following medications do NOT have to be avoided in patients with G6PD deficiency?

6

Which of the following statements regarding MT-RNR1 and aminoglycosides is FALSE?

 
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