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Bases fisiológicas de la terapia antitrombótica

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Bases fisiológicas de la terapia antitrombótica

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Played 7 %Accuracy 84 Average time 01:15
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Bases fisiológicas de la terapia antitrombótica actividad

Created by

Sara Sofia Jaramillo
Sara Sofia Jaramillo
Colombia

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Bases fisiológicas de la terapia antitrombótica
 

Bases fisiológicas de la terapia antitrombóticaOnline version

Bases fisiológicas de la terapia antitrombótica actividad

by Sara Sofia Jaramillo
1

En un paciente con patología cardiaca, el médico decide iniciar terapia antitrombótica. ¿Cuál de las afirmaciones explica mejor la diferencia entre anticoagulantes y antiagregant es?

2

¿Cuál de los siguientes fármacos requiere activación hepática por CYP2C19 para ejercer su efecto?

3

¿Cuál es el anticoagulante sintético que inhibe selectivamente al factor Xa y tiene bajo riesgo de HIT?

Explicación

El clopidogrel es un profármaco que necesita ser activado en el hígado por el sistema CYP450, especialmente CYP2C19. Mutaciones genéticas o inhibidores de CYP2C19 (como omeprazol) pueden reducir su eficacia.

El fondaparinux es un pentasacárido sintético que inhibe de forma altamente selectiva al factor Xa. Tiene 100% biodisponibilidad SC, vida media larga y bajo riesgo de trombocitopenia inducida por heparina (HIT).

 
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