Quiz: PG Induction MCQ Series


PG Induction MCQ SeriesOnline version Antimicro. Susc. Testing by JR1 PG 1 The primary purpose of antimicrobial susceptibility testing (AST) is to: a Identify the bacterial species b Determine the virulence of the organism c Predict the likelihood of clinical success with a drug d Measure antibiotic concentration in serum 2 The standard inoculum density for Kirby–Bauer disk diffusion is: a 1 McF b 0.5 McF c 2 McF d 0.1 McF 3 Which medium is routinely recommended for disk diffusion AST? a MacConkey agar b Chocolate agar c Blood agar d Mueller–Hinton agar 4 The “15–15–15 rule” in disk diffusion refers to: a 15 mm minimum zone for susceptibility b 15 min between inoculum prep, disc placement, and incubation c 15 hours incubation at 15°C d 15 discs per plate 5 If the inoculum is heavier than 0.5 McFarland, the most likely effect is: a b Larger zone sizes c No change d False increase in MIC only 6 In EUCAST terminology, the category “I” means: a Ineffective b Indeterminate c Intermediate d Susceptible, increased exposure 7 Breakpoints are determined based on: a Only in vitro zone sizes b Only pharmacokinetics c PK/PD, clinical outcomes, resistance mechanisms, and MIC distributions d Arbitrary consensus 8 Zone diameters in disk diffusion are measured: a From the top of the plate b From the back of the plate in millimeters c Including the disc diameter d Using centimeters 9 Which situation most strongly indicates the need for MIC testing instead of only disk diffusion? a Severe bloodstream infection b Routine UTI c Skin abscess d Colonization sample 10 A plate shows small zones for all antibiotics tested. The most likely technical cause is: a Low agar depth b Discs placed too close c Light inoculum d Heavy inoculum Feedback 1 AST predicts probability of therapeutic success at standard (or optimized) dosing using defined breakpoints. 2 0.5 McFarland (~1–2 × 10⁸ CFU/mL) ensures standardization. Too heavy → falsely small zones. 3 Mueller–Hinton agar is standardized for pH, cation content, and reproducibility. 4 Use inoculum within ~15 min Place discs within 15 min of inoculating plate Start incubation within 15 min after disc placement 5 Heavy inoculum → more bacterial growth → smaller inhibition zones → false resistance. 6 EUCAST defines “I” as “Susceptible, increased exposure.” It does NOT mean resistant 7 Breakpoints integrate microbiology + PK/PD + clinical evidence. 8 Measured in mm from the back with reflected light. Disc diameter is not included separately. 9 In severe infections (e.g., BSI, endocarditis), precise MIC helps guide dosing decisions. 10 Heavy inoculum commonly produces uniformly reduced zone sizes.

1

The primary purpose of antimicrobial susceptibility testing (AST) is to:

a

Identify the bacterial species

b

Determine the virulence of the organism

c

Predict the likelihood of clinical success with a drug

d

Measure antibiotic concentration in serum

2

The standard inoculum density for Kirby–Bauer disk diffusion is:

a

1 McF

b

0.5 McF

c

2 McF

d

0.1 McF

3

Which medium is routinely recommended for disk diffusion AST?

a

MacConkey agar

b

Chocolate agar

c

Blood agar

d

Mueller–Hinton agar

4

The “15–15–15 rule” in disk diffusion refers to:

a

15 mm minimum zone for susceptibility

b

15 min between inoculum prep, disc placement, and incubation

c

15 hours incubation at 15°C

d

15 discs per plate

5

If the inoculum is heavier than 0.5 McFarland, the most likely effect is:

a

b

Larger zone sizes

c

No change

d

False increase in MIC only

6

In EUCAST terminology, the category “I” means:

a

Ineffective

b

Indeterminate

c

Intermediate

d

Susceptible, increased exposure

7

Breakpoints are determined based on:

a

Only in vitro zone sizes

b

Only pharmacokinetics

c

PK/PD, clinical outcomes, resistance mechanisms, and MIC distributions

d

Arbitrary consensus

8

Zone diameters in disk diffusion are measured:

a

From the top of the plate

b

From the back of the plate in millimeters

c

Including the disc diameter

d

Using centimeters

9

Which situation most strongly indicates the need for MIC testing instead of only disk diffusion?

a

Severe bloodstream infection

b

Routine UTI

c

Skin abscess

d

Colonization sample

10

A plate shows small zones for all antibiotics tested. The most likely technical cause is:

a

Low agar depth

b

Discs placed too close

c

Light inoculum

d

Heavy inoculum

Feedback

1

AST predicts probability of therapeutic success at standard (or optimized) dosing using defined breakpoints.

2

0.5 McFarland (~1–2 × 10⁸ CFU/mL) ensures standardization. Too heavy → falsely small zones.

3

Mueller–Hinton agar is standardized for pH, cation content, and reproducibility.

4

Use inoculum within ~15 min Place discs within 15 min of inoculating plate Start incubation within 15 min after disc placement

5

Heavy inoculum → more bacterial growth → smaller inhibition zones → false resistance.

6

EUCAST defines “I” as “Susceptible, increased exposure.” It does NOT mean resistant

7

Breakpoints integrate microbiology + PK/PD + clinical evidence.

8

Measured in mm from the back with reflected light. Disc diameter is not included separately.

9

In severe infections (e.g., BSI, endocarditis), precise MIC helps guide dosing decisions.

10

Heavy inoculum commonly produces uniformly reduced zone sizes.

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PG Induction MCQ Series

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PG Induction MCQ SeriesOnline version

by JR1 PG

The primary purpose of antimicrobial susceptibility testing (AST) is to:

The standard inoculum density for Kirby–Bauer disk diffusion is:

Which medium is routinely recommended for disk diffusion AST?

The “15–15–15 rule” in disk diffusion refers to:

If the inoculum is heavier than 0.5 McFarland, the most likely effect is:

In EUCAST terminology, the category “I” means:

Breakpoints are determined based on:

Zone diameters in disk diffusion are measured:

Which situation most strongly indicates the need for MIC testing instead of only disk diffusion?

A plate shows small zones for all antibiotics tested. The most likely technical cause is:

Feedback

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