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Osteosarcoma Quiz

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Osteosarcoma Quiz

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Osteosarcoma basics Quiz

Created by

Paloma De La Rosa
Paloma De La Rosa
Mexico

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Osteosarcoma Quiz
 

Osteosarcoma QuizOnline version

Osteosarcoma basics Quiz

by Paloma De La Rosa
1

Osteosarcoma is a malignant primary bone tumor characterized by the production of immature bone (osteoid) by cancer cells. It is the most common primary bone cancer in children and adolescents.

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2

By Location Intramedullary (central) → most common Surface (juxtacortical): Parosteal (low grade) Periosteal (intermediate grade) High-grade surface

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3

By Histologic Subtype Osteoblastic Chondroblastic Fibroblastic Telangiectatic (more aggressive, cystic appearance)

4

Causes Exact cause is unknown, but associated with: Genetic Factors RB1 mutation → Retinoblastoma TP53 mutation → Li-Fraumeni syndrome Environmental / Medical Prior radiation therapy Rapid bone growth (adolescence) Other Associations Paget disease of bone (in older adults)

5

Diagnosis - Imaging X-ray findings: “Sunburst pattern” (periosteal reaction) Codman triangle MRI → local extent CT chest → lung metastasis

6

Diagnosis - Laboratory ↑ Alkaline phosphatase (ALP) ↑ Lactate dehydrogenase (LDH)

7

Definitive Diagnosis Bone biopsy → malignant osteoid production

8

Chemotherapy Neoadjuvant (before surgery) Adjuvant (after surgery) Common drugs: Methotrexate Doxorubicin Cisplatin

9

Metastasis Management Surgical removal of lung metastases, is a type of

 
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