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KUIS FARMAKOKINETIKA

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KUIS FARMAKOKINETIKA

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pendalaman materi farmakokinetika

Created by

Dea Iftitah Risky Ananda
Dea Iftitah Risky Ananda
Indonesia

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KUIS FARMAKOKINETIKA
 

KUIS FARMAKOKINETIKAOnline version

pendalaman materi farmakokinetika

by Dea Iftitah Risky Ananda
1

Proses pergerakan obat dari tempat pemberiannya ke dalam sirkulasi sistemik disebut dengan...

2

Hubungan matematis antara Klirens (Cl), Volume Distribusi (Vd), dan konstanta laju eliminasi (k) digambarkan oleh rumus...

3

Seorang pasien diberikan dosis tunggal obat secara intravena sebesar 500 mg. Sesaat setelah penyuntikan, konsentrasi obat dalam plasma diukur dan hasilnya adalah 25 mg/L. Berapakah volume distribusi (Vd) obat tersebut pada pasien?

4

Nilai AUC untuk pemberian obat secara oral (dosis 100 mg) adalah 50 mg}\jam/L. Sedangkan nilai AUC untuk pemberian obat yang sama secara intravena (dosis 100 mg) adalah 100\mg/jam/L. Berapakah bioavailabilitas absolut (F) dari sediaan oral tersebut?

5

Seorang pasien membutuhkan konsentrasi plasma tunak (Css) suatu obat sebesar 15\mg/L. Jika diketahui volume distribusi (Vd) obat tersebut adalah 30\L, berapakah dosis muatan (loading dose) intravena bolus yang harus diberikan?

6

Sebuah obat memiliki waktu paruh (t1/2) sebesar 2 jam. Berapakah konstanta laju eliminasi (k) obat tersebut jika mengikuti eliminasi orde kesatu?

7

Seorang pasien dengan berat badan 60 kg diberikan obat yang memiliki volume distribusi spesifik 0.5\L/kg. Berapakah nilai volume distribusi (Vd) total obat tersebut di dalam tubuh pasien?

8

Diketahui t1/2 suatu obat ada 3 jam. Berapakah waktu yang dibutuhkan untuk wash out?

9

Apabila pasien mengonsumsi obat yang bersifat sebagai 'Enzyme Inducer' (Induktor Enzim) sitokrom P450 secara bersamaan dengan obat lain (substrat), efek yang kemungkinan besar terjadi pada obat substrat adalah...

10

Parameter farmakokinetika manakah yang paling akurat digunakan untuk menggambarkan total paparan sistemik atau jumlah total obat aktif yang berada di dalam tubuh setelah pemberian suatu dosis?

 
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