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Fisiología Molecular de la Tiroides

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Fisiología Molecular de la Tiroides

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Conceptos clave en hormonas tiroideas

Created by

abigail cobo
abigail cobo
Ecuador

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Fisiología Molecular de la Tiroides
 

Fisiología Molecular de la TiroidesOnline version

Conceptos clave en hormonas tiroideas

by abigail cobo
1

¿Qué proteína sirve como andamiaje para la síntesis de T3 y T4 en la tiroides?

2

¿Qué enzima convierte T4 en T3 dentro de las células?»

3

Qué proteína transporta yodo hacia la tiroides?

4

¿Dónde ocurre la organificación del yodo en la tiroides?

5

¿Qué hormona regula principalmente la captación de yodo y la producción de T3/T4?

6

¿Qué deshidrogenasa es clave para la activación/desactivación de T3 y T4?

7

¿Qué mecanismo regula la secreción tiroidea en el eje hipotálamo-hipófiso?

8

¿Qué transportador permite la salida de T4/T3 a la sangre?

9

¿Qué proteína almacena iodo dentro de la tiroides?

10

¿Qué efecto principal de T3 en la célula?

Explicación

La tiroglobulina actúa como precursor y sustrato para la organificación de yodo y la formación de T3/T4.

Las deiodinasas (D1, D2) convert> T4 a T3 activando la hormona.

NIS facilita la captación de yodo desde la sangre en la tiroides.

La organificación implica yodación de la tiroglobulina en la membrana apical.

La TSH estimula NIS, TPO y la thyroglobulina para producir hormonas tiroideas.

Las deiodinasas convierten T4 en T3 (activa) o en rT3 (inactiva).

T4/T3 inhiben la liberación de TRH y TSH cuando sus niveles son altos.

MCT8 facilita el transporte de hormonas tiroideas a tejidos.

La tiroglobulina almacena yodo y sirve de sustrato para sintetizar T3/T4.

T3 se une a receptores nucleares y regula la expresión génica para metabolismos.

 
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