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CYP450: Farmacocinética

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CYP450: Farmacocinética

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About this activity

Quiz sobre metabolismo de fármacos

Created by

Zusan Gadeas
Zusan Gadeas
Panama

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CYP450: Farmacocinética
 

CYP450: FarmacocinéticaOnline version

Quiz sobre metabolismo de fármacos

by Zusan Gadeas
1

¿Qué CYP450 es responsable de la mayor parte de la metabolización de fármacos en el hígado?

2

¿Cuál es la isoforma asociada a variabilidad genética en metabolismo rápido o lento?

3

¿Qué fármaco es un potente inductor de CYP3A4?

4

¿Qué tipo de reacción cataliza CYP450?

5

¿Qué proceso no es catalizado por CYP450?

6

¿Cuál CYP suele formar metabolitos activos de muchos antidepresivos?

7

¿Qué factor más influye en la actividad de CYP450?

8

¿Qué fármaco es sustrato típico de CYP3A4?

9

¿Qué caracteriza a la expresión de CYP3A5?

10

¿Qué inducción de CYP3A4 puede ocurrir con ciertos fármacos?

Explicación

CYP3A4 maneja ~50% de los fármacos; las demás isoformas son menos frecuentes.

CYP2D6 presenta polimorfismos que producen fenotipos de metabolizadores rápido o lento.

La rifampicina induce la expresión de CYP3A4 aumentando el metabolismo de muchos fármacos.

La familia CYP cataliza reacciones de oxidación, entre otras, facilitando metabolitos más hidrofílicos.

La conjugación glucurónido es típica de UGT, no de CYP450.

CYP2D6 metaboliza muchos antidepresivos a metabolitos activos.

Interacciones, inducción/inhibición y variabilidad genética modifican la actividad.

Midazolam es un sustrato bien conocido de CYP3A4.

CYP3A5 se expresa de forma polimórfica en humanos, afectando metabolismo.

La carbamazepina es un conocido inductor de CYP3A4 aumentando el metabolismo de otros fármacos.

 
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